Our ongoing investments in research and clinical discovery drive our innovation. We ensure the benefits of our products are thoroughly researched, and claims surrounding AG1 Next Gen are substantiated by multiple bodies of research on ingredients and the finished formula. The impact of AG1 Next Gen is not just experienced, it's measurable–with 4 published clinical trials and more planned.*1-4
AG1 Next Gen has been put to the test in multiple gold-standard clinical trials, consistently showing its efficacy in closing nutrient gaps and supporting gut health across diverse populations and study designs.*
Even with a food-first approach to nutrition, healthy eaters can have gaps in their diets. Nutrient requirements are based on estimates of what most people need, and they don’t account for specific genetics, gut health, or bioavailability. While individual nutrient gaps vary from day to day, we found that across 157 participants from four clinical trials, 87% had at least 1 dietary nutrient gap, and 54% had at least 4. Adding AG1 Next Gen to participants' diet was clinically shown to help fill key nutritional gaps across these healthy individuals, complementing their day-to-day diet.
of nutrient requirements met
with Diet + Placebo
of nutrient requirements met
with Diet + AG1
WHY THIS MATTERS
In four randomized, placebo-controlled trials—meeting strict and widely accepted standards for clinical research—AG1 Next Gen demonstrated a statistically significant and positive impact on closing common nutrient gaps. These studies included participants with diverse diets, backgrounds, ages, and activity levels.¹⁻⁴ Adding AG1 Next Gen to participants' diets was clinically shown to help fill key nutritional gaps in these healthy individuals, complementing their day-to-day diet.
Nutrient levels and biomarkers are indicators of certain regulated health functions in the body because of the complex interplay between an individual’s unique biology and their nutrient utilization. Optimizing and tracking nutrient levels and associated biomarkers is a measurable indicator that a supplement is effectively supporting healthy bodily processes over time. We examined the impact of AG1 Next Gen on key nutrient biomarkers compared to diet alone and assessed its impact at the cellular level by evaluating RBC folate—a sensitive and accurate measure of folate status.
7 in 10 subjects drinking AG1 Next Gen had an increase in RBC folate.1
subjects drinking AG1 Next Gen had an increase in RBC folate.
WHY THIS MATTERS
Adequate micronutrient intake is needed to support the body in producing energy, building proteins, and metabolizing food. They act as co-factors and individual building blocks. Maintaining consistent intake is key for overall health.*
increase in Vitamin C levels1
WHY THIS MATTERS
Vitamin C supports the body's ability to combat oxidative stress and support immune defenses. It is a super antioxidant that plays a fundamental role in various physical and cellular processes.*
In three randomized controlled trials that included participants with varying diet quality, age, and activity levels, AG1 Next Gen was shown to enrich key probiotic species in the gut. This was measured using whole-genome shotgun metagenomic sequencing, the gold standard tool for structural assessment of microbial taxa. The replication of results across multiple trials further validates our findings and is strengthened by the fact that healthy bacteria began to decrease when AG1 Next Gen was discontinued. This leads to more confident conclusions in our research and a better understanding that AG1 Next Gen’s probiotics survive the GI tract and reach the colon to exert their desired effect.
Average increase in healthy bacteria in the gut1-3
WHY THIS MATTERS
Beneficial bacteria—such as the probiotic strains in AG1 Next Gen—are important for maintaining a healthy microbiome and play a key role in supporting overall gut health.*
Bioavailability measures how well your body can absorb any given nutrient. When nutrients are bioavailable, it means your body has access to them and can use them for potential benefits. Factors such as dosage, formulation, and individual physiology can affect bioavailability, influencing a vitamin's effectiveness in performing essential functions and delivering intended benefits. Unlike some supplements that use ingredients in forms that are difficult to bypass the gut and never enter the bloodstream, AG1 used a crossover clinical trial to assess how key nutrients were absorbed and available to be used by the body.
We found that AG1 delivers key nutrients in forms the body can absorb and use.
AG1 Next Gen delivers key nutrients like folate, vitamin C, and zinc—in bioavailable forms the body can easily and readily utilize, maximizing their potential benefits.*
Folate levels were significantly increased within 30 minutes of drinking AG1 Next Gen.4
WHY THIS MATTERS
AG1 Next Gen delivers key nutrients like folate, vitamin C, and zinc—in bioavailable forms the body can easily and readily utilize, maximizing their potential benefits.* Folate levels were significantly increased within 30 minutes of drinking AG1 Next Gen.⁴
1 Triple-blind, randomized, placebo-controlled, parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults aged 20-59 over the course of 12 weeks.
2 Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults aged 19-37.
3 Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 24 healthy adults with occasional GI distress, ages 26-59.
4 Double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults aged 18-42 over the course of 8 hours.
We collaborate with a diverse network of leading universities, contract research organizations (CROs), and independent research institutions to support the design, execution, and publication of rigorous clinical trials. These partnerships bring together multidisciplinary scientific expertise and global research capabilities to advance high-quality, evidence-based outcomes across our clinical research projects.
