Our Commitment to Science

Our formulas are developed and continuously reviewed by a multidisciplinary team of clinicians, PhDs, and independent advisors. The team’s oversight spans formulation, clinical research, and ongoing scrutiny of the emerging science, so that our product evolves as science emerges.

Scientific Expertise

Clinical Contribution

Our experts have authored or contributed to over 500 research studies and abstract publications in top-tier, high-impact scientific journals.

Formal Academic Excellence

The Research and Development Team and our Science and Innovation Board include researchers and clinicians trained at top-tier medical, kinesiology, nutrition, and food science institutions across the country.

Product Formulation Expertise

The Research and Development Teams have supported the development of more than 250 dietary supplements, technologies, and health applications to advance nutrition science.

Our Advisors

Our independent Science and Innovation Advisors bring deep expertise across nutrition science, health, and research. They work alongside our in-house team to provide guidance on research and product development, helping to ensure our work remains rigorous, forward-looking, and grounded in evidence.

Peer-reviewed research

Beyond sharing our findings online and at national conferences, we work with leading researchers to submit study manuscripts to peer-reviewed scientific journals—contributing to the broader scientific dialogue on the vital role of nutrition and the microbiome in overall health.

Authors: Adam M. Gonzalez, Jeremy R. Townsend, Philip A. Sapp, Caitlyn Edwards, Trevor O. Kirby, Justin Wright, Regina Lamendella, and Ralph Esposito

Journal and Year: Frontiers in Nutrition 2026

Study Type: Randomized, double-blind, placebo-controlled crossover study

Contribution: Authors consist of academic faculty from Hofstra, external scientists, and members of the AG1 scientific and research team

Key observations: A 2-week crossover clinical trial including 20 healthy, physically active, adults found that AG1® supplementation was associated with selective enrichment of key bacterial taxa, including Lactiplantibacillus plantarum, Lacticaseibacillus rhamnosus, and Bifidobacterium animalis. AG1® supplementation significantly improved nutritional adequacy by increasing the total number of micronutrient Estimated Average Requirements (EARs) met compared to placebo. Vitamins A, C, and E were the most common nutrient gaps filled by AG1 supplementation.

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Authors: Caitlyn Edwards, Jeremy R. Townsend, Philip A. Sapp, Trevor O. Kirby, Susanne Mitschke, Scott Conger, Lara Nyman, and Ralph Esposito

Journal and Year: Current Developments in Nutrition 2025; Presented at American Society for Nutrition Annual Conference 2025

Study Type: Randomized, triple-blind, placebo-controlled parallel study

Contribution: Authors consist of external scientists and members of the AG1 scientific and research team

Key observations: A 12-week clinical trial, which enrolled 120 healthy adults (105 included in the analysis) with suboptimal fruit and vegetable intake, found that AG1® significantly increased blood vitamin C, serum folate, red blood cell folate, and decreased homocysteine.

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Authors: Trevor O. Kirby, Jeremy R. Townsend, Philip A. Sapp, Caitlyn Edwards, Justin Wright, Gina Lamendella, Lara Nyman, and Ralph Esposito

Journal and Year: Abstract presented at ASM Microbe 2025

Study Type: Randomized, triple-blind, placebo-controlled parallel study

Contribution: Authors consist of external scientists and members of the AG1 scientific and research team

Key observations: A 12-week clinical trial, which enrolled 120 healthy adults (99 included in the analysis) with suboptimal fruit and vegetable intake, found that AG1 supplementation led to significant enrichment of several taxa, including Bifidobacterium animalis, Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Lacticaseibacillus casei, and Lactiplantibacillus plantarum. Further, the enrichment of various taxa caused several gene pathways to have greater representation within the microbiome, implying potential metabolic benefits that could be conferred to the host.

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Authors: Philip A. Sapp, Jeremy R. Townsend, Caitlyn Edwards, Trevor O. Kirby, Susanne Mitschke, Scott Conger, Lara Nyman, and Ralph Esposito

Journal and Year: Current Developments in Nutrition 2025; Presented at American Society for Nutrition Annual Conference 2025

Study Type: Randomized, triple-blind, placebo-controlled parallel study

Contribution: Authors consist of external scientists and members of the AG1 scientific and research team

Key observations: A 12-week clinical trial, which enrolled 120 healthy adults (98 included in the analysis) with suboptimal fruit and vegetable intake, found that AG1® consumption significantly improves nutrient adequacy by reducing nutrient gaps.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.